Felodipine Test Basket

The USP Monograph specifications for felodipine extended-release tablets require the use of a four-sided stationary basket. The Huanzheng stationary basket fully complies with the USP Monograph requirements.

The Huanzheng Felodipine Basket is made of precisely welded stainless steel mesh, and the basket is securely fixed to the shaft, preventing it from easily bending or detaching.

The basket also features a small lid to prevent tablets from slipping out during testing. This lid is manufactured in a way that ensures it will not detach or be lost during use.

USP 26 requires the use of a basket that maintains a precise distance from the paddle shaft, which necessitates the use of a modified container lid.

Key Considerations

The Stationary Basket method offers a potential solution to problems associated with floating, sticking, and swelling drug formulations.

While using sinkers may also address similar issues, their final position in the dissolution vessel can vary, leading to discrepancies in test results—differences that can be eliminated by using the stationary basket method. (Suitability for certain applications must be verified.)

Purpose and function

 1. To address floating, sticking, or swelling: Extended-release tablets can float, causing issues in standard paddle-based dissolution tests. The stationary basket prevents this by holding the tablet in a fixed position relative to the paddle.

 2.  To meet USP standards: This specific basket is designed to comply with USP 26 requirements, which specify its use in the analysis of felodipine extended-release tablets.

 3. To ensure accurate drug release testing: By securing the tablet, the basket ensures that the drug's release rate is accurately measured, which is crucial for a medication's efficacy and safety. 

Key features

  1. Construction: Made from precision-welded steel mesh to prevent corrosion and ensure durability.

  2. Stationary design: The basket is fixed in place, typically from a special vessel cover, at a precise distance from the paddle.

  3. Flap closure: It includes a small flap to securely hold the tablet inside and prevent it from escaping during testing.

  4. Compatibility: Available for use with various dissolution testers from manufacturers like Agilent, Distek, Electrolab, and others.